The 10-OH-HHC is the hydroxy derivative of hexahydrocannabinol (HHC). We have already written quite a bit about HHC in previous articles. It is a cannabinoid discovered in 1944 by Roger Adams when he converted THC to HHC through the hydrogenation process.
10-OH-HHC is produced by the oxidation of HHC with the help of an enzyme found mainly in the liver - cytochrome P450. And what does this process involve? Ten -OH hydroxyl groups, which are oxygen atoms bonded to hydrogen atoms, which are added to HHC.
10-OH-HHC has low bioavailability and a short half-life in the body. This cannabinoid can be further metabolised and converted to the inactive 10-carboxy-HHC.
What are the results of 10-OH-HHC?
Research on 10-OH-HHC is at an early stage, so we have very little information and some of it is based only on assumptions or experience with analogue derivatives.
It appears that 10-OH-HHC could mimic some of the effects of THC and other cannabinoids - this ability is referred to as cannabimimetic activity. In the cannabis world it is heard to be a very potent cannabinoid, and so a strong affinity for the CB1 and CB2 cannabinoid receptors in the endocannabinoid system would also be expected.
However, not much is known about how 10-OH-HHC interacts with the receptors and with what specific intensity. The effects will also depend (in addition to the specific disposition of the individual) on the route of administration, as more of this cannabinoid can be converted to inactive 10-carboxy-HHC by oral administration than by evaporation or sublingual administration.
"Oxygenated" forms of HHC
Scientists are still trying to isolate "oxygenated forms" of the cannabinoids CBD, THC, HHC and others from very potent Cannabis sativa varieties. So, in addition to HHC, HHC-O and HHC-P, there are a number of other similar derivatives such as 7-OH-HHC, 9a-OH-HHC etc.
So what we keep from 10-OH-HHC is the following:
- Natural derivative: 10-OH-HHC is formed in the body through the action of liver enzymes, utilising the intrinsic properties of HHC found in cannabis.
- Endogenous Union: Unlike synthetic cannabinoids, 10-OH-HHC is produced in the body, enhancing its safety profile.
- Verified safety: It has been extensively tested to ensure its safety, giving you confidence in its use.
- Strong results: Known for its strong effect on CB1 and CB2 receptors, 10-OH-HHC promises significant physiological effects.
We still have to wait for research and scientific studies and products with 10-OH-HHC to learn more.
